RESEALED ERYTHROCYTES AS CARRIERS AND ITS APPLICATION IN THERAPY

The aim of the present review is to focus on the various features, drug loading technology and biomedical application of resealed erythrocytes. Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body, biocompatibility, zero order release kinetics, reproducibility and ease of preparation.. Erythrocytes are biocompatible, biodegradable, possess long circulation half lives, and can be loaded with a variety of biologically active compounds using various chemical and physical methods (Hypotonic dilution, Hypotonic hemolysis, Electro-insertion, entrapment by endocytosis, Hypoosmotic lysis). Most of the resealed erythrocytes used as drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system (RES), which is present in liver, lung, and spleen of the body. So many drugs like aspirin, steroid, cancer drug which having many side effects are reduce by resealed erythrocyte. The present article gives information about morphology, isolation, properties, and methods of drug loading, characterization, mechanism, and applications of resealed erythrocytes.