Pinanyl-2-aminopyrimidine compounds as well as synthesis method and application thereof

The invention discloses pinanyl-2-aminopyrimidine compounds as well as a synthesis method and application thereof. The synthesis method comprises the following steps: by taking beta-pinene as a raw material, selectively oxidizing to obtain (+)-nopinone; carrying out aldol condensation with aromatic aldehyde to obtain 3-aryl methylene nopinone; then, carrying out cyclization reaction with guanidine hydrochloride to obtain the pinanyl-2-aminopyrimidine compounds. According to the invention, the pinanyl-2-aminopyrimidine compounds are synthesized by special space structures so as to screen the compounds with effective antineoplastic activity by using the main component beta-pinene in the most abundant natural extract turpentine in China, so that the source of antineoplastic drugs is expanded, and the compounds are of significance to the field of utilization of turpentine in China. The isopinanyl-2-aminopyrimidine compounds have good antineoplastic activity to human breast cancer cell MCF-7, human lung cancer cell A549 and human hepatoma carcinoma cells HepG2 and SMMC-7721.