SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF PYRAZOLINE & AMINO CYANOPYRIDINE DERIVATIVES OF WITH VANILLIN

Pyrazoline derivatives 3-Aryl-5-(4'-(p-chlorobenzyloxy)-3'-methoxyphenyl)-1-(p-fluorophenyl)-4,-5-dihydro-1H- pyrazoles and cyanopyridine derivative of 2-amino-6-aryl-4-(4'-(p-chlorobenzyloxy)-3'-methoxyphenyl)-2-methoxy-3- cyanopyridines were prepared. All the prepared compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities. acquired a special attention due to their wide range of therapeutic activities. The pyridine nucleus is found in a large number of commonly used drugs, which have diverse pharmacological activities. Interests in the synthesis of multicyclic pyridine containing compounds have increased in recent years because of their biological and pharmacological activities. This inspired us to synthesize 3-aryl-5-(4'-(p-chlorobenzyloxy)- 3'-methoxyphenyl)-1-(p-fluorophenyl)-4,-5-dihydro-1H-pyrazoles (1a-l) and cyanopyridine derivative 2-Amino-6-aryl-4-(4'-(p-chlorobenzyloxy)-3'-methoxyphenyl)-2-methoxy-3-cyanopyridines (2a-l). The structure of synthesized compounds were assigned based on elemental analysis, IR 1 H-NMR and Mass spectral data. The antimicrobial activity was assayed by using the cup-plate agar diffusion method 24 by measuring the zone of inhibition in mm. All the compounds were screened in vitro for their antimicrobial