Study on the Electrochemical Behavior of Picoplatin and Interaction of Picoplatin with DNA at Glassy Carbon Electrode

The electrochemical behavior of picoplatin at multi-walled carbon nanotubes ionic liquids modified glassy carbon electrode(MWNTs-[ODMIM]PF6/GCE) was investigated by cyclic voltammetry and differential pulse voltammetry, and the method of picoplatin determination was established. The mode of intercalation between picoplatin with DNA was studied by electrochemical methods combined with UV-visible spectroscopy. The results show that one pair of redox peaks of picoplatin was obtained at MWNTs-[ODMIM]PF6/GCE by cyclic voltammetry with-0.07 V of Epa and-0.36 V of Epc, ΔE=0.29 V, and Ipa/Ipc=1.11. Under optimal conditions, the oxidization peak current was linearly related to the concentration of picoplatin in the range of 2.66~532 μmol/L with the detection limit of 1.33 μmol/L. The method was convenient, accurate, credible and sensitive, it can be used in the direct determination of picoplatin.