Cyclin E overexpression in transitional cell carcinoma of the bladder

We attempted to clarify the relationship between cyclin E to p27Kip1, Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin–biotin–peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlated with histological grade, Ki-67 LI and p27Kip1 labeling index (LI). These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27Kip1 for the regulation of cell cycle progression in transitional cell bladder carcinoma.