Regulation of c-Jun signaling pathway in peripheral nerve demyelination

After peripheral nerve injury (PNI), myelinated Schwann cells undergo demyelination, dedifferentiation and proliferation, then migrate along basal lamina tubes and align to form the longitudinal cell strands known as bands of Bungner, which creates suitable conditions for axonal regeneration and remyelination. By reviewing literature, we found that the expression of a transcriptional factor c-Jun increased during demyelination process after PNI, and increasing evidences suggested that demyelination and c-Jun signaling pathways were closely related. This review summarized the research situation and progress of c-Jun signaling pathways regulating demyelination process after peripheral nerve injury. Key words: c-Jun; Peripheral nerve injury; Demyelination; Signaling pathway