Efficacy and tolerance of pantoprazole 40mg vs 80mg in patients with reflux oesophagitis - a multicentre study

PATIENTS AND METHODS: 192 outpatients (intention-to-treat; 97 on 40mg and 95 on 80rag) of both sexes with endoscopically confirmed RO (stag e II or III Savary/Miller classification) were entered. The primary evaluation criterion was end0scopically confirmed complet e healing of the RO. Improvement in typical reflux symptoms and other gastrointestinal symptoms, as well as drug tolerability and safety were recorded. Healing rates after 4 and 8 weeks were analysed using the Cochran/ManteI-Haenszel method.