593 Chronic Urticaria as First Sign of Sarcoidosis.

Background Sarcoidosis is a granulomatous multisystemic disease of unclear etiology, which can affect any organ. The cutaneous manifestations are present in 20% to 35% of patients. Cutaneous lesions have been classified as specific and nonspecific, depending on the presence of noncaseating granulomas on histologic studies. Specific lesions include maculopapules, plaques, nodules, lupus pernio, scar infiltration, alopecia, ulcerative lesions, and hypopigmentation among others. The most common nonspecific lesion is erythema nodosum. Others include calcifications, prurigo, erythema multiforme, nail clubbing, and sweet syndrome. Urticaria does not belong to nonspecific nor specific lesions of this illness. Diagnosis is based on 3 criteria: a compatible clinical and/or radiological picture, histological evidence of noncaseating granulomas, and exclusion of other diseases. There is no standarized therapy but corticosteroids are the mainstay of treatment for sarcoidosis. We report a case of undetermined chronic urticaria which after 6 months displayed compatible symptoms with respiratory disease associated with systemic involvement.