The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

A. Carolin Seefeldt,Fabian Nguyen,Stéphanie Antunes,Natacha Pérébaskine,Michael Graf,Stefan Arenz,Krishna Kishore Inampudi,Céline Douat,Gilles Guichard,Daniel N. Wilson,C. Axel Innis

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

2015

A. Carolin Seefeldt
Fabian Nguyen
Stéphanie Antunes
Natacha Pérébaskine
Michael Graf
Stefan Arenz
Krishna Kishore Inampudi
Céline Douat
Gilles Guichard
Daniel N. Wilson
C. Axel Innis

Structural and biochemical studies reveal how the antimicrobial peptide Onc112 binds to bacterial ribosomes and show that Onc112 blocks and destabilizes the translation-initiation complex.

Keywords:

Proline
Antimicrobial
Biochemistry
Molecular biology
Ribosome
Peptide
Biology
proline rich

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