Snail slime-based gold nanoparticles: An interesting potential ingredient in cosmetics as an antioxidant, sunscreen, and tyrosinase inhibitor.

Abstract Due to their properties, snail slime-based products have been appreciated and used worldwide. So, as an alternative and innovative use of snail slime, it was adopted to induce gold nanoparticles' formation, conferring them interesting properties. By a simple, one-pot, and eco-friendly approach, 14 ± 6 nm wide hybrid gold nanoparticles, having an inorganic metallic core decorated by the slime's main components, were obtained. Among their several properties, their antioxidant and tyrosinase inhibition activity were investigated through the DPPH and ABTS and the tyrosinase assays, respectively. After assessing their non-cytotoxicity in our previous work, the results revealed positive responses, enabling their use as a potential novel multifunctional ingredient in cosmetics. Interestingly, the gold nanoparticle photostability, investigated by means of a solar simulator lamp, suggests using them in commercial cosmetic sunscreen products as a potential alternative to the commonly used inorganic sunscreen ingredients. The theoretical Sun Protection Factor was evaluated, obtaining values in the range 0–12. The proposed environmentally friendly and cost-effective protocol for nanoparticle synthesis, following the principles of Green Chemistry, opens a hugely attractive space toward the study of snail slime-based gold nanoparticles as a potential multipurpose platform in cosmetics.