Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers

One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCl 2 .2H 2 O affords eight different substituted 3,4-dihydropyrimidine ones/ thiones. Further we prepared acetylated 3,4-dihydropyrimidine ones/thiones, on treatment of 3,4-dihydropyrimidine ones/thiones with acetic anhydride using zinc chloride as a catalyst. Calcium channel blocker activity shows that synthesized compounds have moderate activity.