A phase I dose-escalation and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced cancer

Stephen Leong,R. Camidge,G. Eckhardt,Michele Basche,L. Musib,Christelle Darstein,Donald Thornton,Carolyn D. Britten

A phase I dose-escalation and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced cancer

2016

Stephen Leong
R. Camidge
G. Eckhardt
Michele Basche
L. Musib
Christelle Darstein
Donald Thornton
Carolyn D. Britten

2048 Background: Enzastaurin (ENZ), an oral inhibitor of protein kinase C (PKC), affects signal transduction associated with angiogenesis, proliferation, and survival. The combination of ENZ and ca...

Keywords:

Capecitabine
Signal transduction
Protein kinase C
Cancer
Angiogenesis
Pathology
Enzastaurin
Cancer research
Medicine
Pharmacokinetics
in patient
dose escalation

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