Citogenómica en leucemia linfoblástica aguda

In acute lymphoblastic leukemia (ALL), various types of chromosomal alterations with prognostic value are reported well known, these changes allow us to evaluate the response to treatment and survival. Cytogenomics currently allows to know the behavior of leukemias using high-density microarrays, as it has been observed that higher detection. With microarrays can detect losses that are closely related genes as clinically; CDKN2A/B, ETV6, PAX5 and IKZF1, which are associated with the expression and regulation of genes that contribute to neoplastic transformation in hematopoiesis and are located in cells of type B. With these technological advances in microarray platforms, we have allowed more knowledge to understand the processes of leukemogenesis, for therapeutic targets, and deliver personalized medicine. But we still need to understand mechanisms that allow us to identify why there are differences in the origin and frequency of chromosome abnormalities among children and adults.