Solvent controlled aggregation behavior of peptide bond simulant N-methylacetamide and vibrational coupling splitting theory

Abstract Quantum state of C = O streching presents as two entangled quantum states, one is in phase and another is out phase when adjacent C = O coupled in aggregated dimers form. As the simplest model molecules of peptide, N-methylacetamide in binary mixture were chosen to investigate the intermolecular C = O coupling. The isotropic and anisotropic Raman spectra of N-methylacetamide/CCl4, N-methylacetamide/ methanol, N-methylacetamide/ acetonitrile, N-methylacetamide/ methanol and N-methylacetamide/ water binary mixture at different concentrations have been obtained. It was found that the quantum frequencies and strength of quantum entanglement could be continuously tuned span