Transition to resistance: An unexpected role of the EMT in cancer chemoresistance

Abstract Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance. 1,2 While these findings may not settle the EMT's role in metastasis, these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance.