Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant

AbstractObjective: Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).Methods: Biomarkers were measured in 67 KTR with AKI caused by different entities.Results: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p  200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81–0.97). uNGAL may be useful to predict graft loss after AKI.