Nanodomain cubic copper (I) oxide as reusable catalyst for the synthesis of amides by amidation of aryl halides with isocyanides

Abstract An environmentally benign chemical process for the C–C coupling of aryl halides with isocyanides in aqueous medium has been developed using cubic copper (I) oxide nanoparticles as reusable catalyst. The use of nano-catalyst eliminates the use of any stabilizing ligands or additives as well as the use of organic solvents. The catalyst exhibited comparable efficiency up to three recycles and was found to be very effective for the synthesis of varied amides leading to biologically significant scaffold.