A Novel and Efficient Synthesis of a Tetra-Substituted Imidazole.

Abstract A novel synthesis of a tetra-substituted imidazole is described. A key feature of the synthesis is the regioselective deprotonation of picolylpyrrolidinone 3 and the efficient reaction of this anion with an aryl nitrile to give the pyrrolidinoimidazole nucleus in a single step.