규폐증에서 Gallium-67 신티그라피의 정량적인 분석 : 흉부 X- 선과 폐기능검사화의 비교

Purpose:The International Labor Organization (ILO) has established an international standard for chest X-ray diagnosis of pneumoconiosis since 1980. However, there is a need for improved diagnosis and staging in occupational disease. We evaluated Ga-67 citrate scintigraphy quantitatively and correlated the scintigraphic findings with pulmonary function tests and chest X-ray results. Materials and Methods: Twenty- five patients underwent whole body scintigraphy with additional chest and abdomen images 48 hrs after intravenous injection of 185 MBq of Ga-67 citrate. Ten normal controls were also studied. Regions of interest (ROI) were drawn on the posterior image to measure counts from the liver and lungs (Lung/Liver Ratio). Results: L/L ratio according to the stages of chest X-ray classification were as follows; stage 0 (normal, n=10): 0.3948±0.0692, stage 1 (n=10): 0.5763±0.1837, stage 2 (n=11): 0.6849±0.1459, stage 3 (n=4): 0.9913±0.0712. There was a significant correlation between the scintigraphic L/L ratio and the X-ray stage (r=0.618, p 0.05). Conclusion: Quantitative Ga-67 scintigraphy can be a useful method for staging of silicosis. However, it is not a method to assess pulmonary functional impairment. (Korean J Nucl Med 1999;33:381-7)