Clozapine Intoxication Mimicking Acute Stroke

Author(s): Lebin, Jacob A.; Villarreal, Joshua D.; Chen, Betty C.; Hall, M. Kennedy | Abstract: Clozapine is an atypical antipsychotic drug prescribed for treatment-resistant schizophrenia. The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare. We report a case of accidental acute clozapine intoxication in a clozapine-naive patient, who presented with symptoms mimicking acute stroke and later developed status epilepticus. Clozapine intoxication is a rare presentation in the emergency department with potential for iatrogenic harm if not correctly identified.