A NOVEL 2'-DEOXYNUCLEOSIDE DESIGNED FOR ENHANCED RECOGNITION OF A.T. BASE-PAIRS

Abstract The title base modified purine deoxynucleoside 1 , designed to be incorporated in triplex-forming oligodcoxynucleotides selectively binding to the A.T. base pair, was prepared by non ionic azido-phenylselenylation reaction applied to a 6-vinylpurine substrate.