Total Synthesis of a Diacetonide Derivative of Thuggacin A
2016
A highly stereoselective total synthesis of the diacetonide derivative of the antibiotic thuggacin A has been described. The synthesis features the stereoselective Stille cross-coupling reaction to set up the whole carbon framework, aldol condensation to construct the highly substituted conjugated diene, non-Evans syn aldol, CBS reduction, Hantzsch’s thiazole synthesis, Horner–Wadsworth–Emmons reaction, and Shiina’s macrolactonization.
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