Particularităţile diagnosticului în limfoamele primare ale sistemului nervos central (PCNSL)

The primary central nervous system lymphoma (PCNSL) is a rare form of extranodal lymphoma that can affect the brain, the leptomeninges, the eye or the spinal cord, without any evidence of a systemic disease, having immunodeficiency as the main risk factor. The clinical presentation varies depending on the affected area. The diagnosis starts with a clinical suspicion, and must be supplemented by laboratory tests (blood and cerebrospinal fluid analysis) and imaging examinations. Even though the therapeutic protocols are limited, using the new treatments significantly increased the overall survival during time, but tumor relapse is still frequent and generally with poor prognosis.