Studies on the synthesis of the antitumor agents esperamicin A1/calicheamicin γ1: stereospecific synthesis of the 12β-hydroxybicyclo[7.3.1] diynene core structure via a Co2(CO)6-acetylene-mediated synclinal aldol reaction

Synthese de t-butyldimethylsiloxy-1 hydroxy-8 bicyclo [7.3.1] tridecene-4 diyne-2,6 one-13 a partir de chloro-4 butene-3 yne-1 yl trimethyl silane, de diethylacetal propynal et de t-butyldimethyl siloxy-2 cyclohexene-2 one via un derive [t-butyldimethylsiloxy-1' oxo-2-cyclohexyl]-7 heptene-4 diyne-2,6 al complexe avec CO 2 (CO) 8