Alkaloids from the Roots of Goniothalamus griffithii

Three new alkaloidsgriffithazanone A (1), griffithdione (2), and griffithinam (3)were isolated from the roots of Goniothalamus griffithii, along with six known compounds, 4-methyl-2,9,10-(2H)-1-azaanthracenetrione (4), velutinam, aristololactam BI, aristololactam BII, aristololactam AII, and norcepharanone B. Their structures were elucidated on the basis of spectral and chemical methods. The absolute configuration of griffithazanone A (1) was determined by the preparation of Mosher's esters.