Neurological andadrenal dysfunction intheadrenal insufficiency/al acrima/achalasia (3A)syndrome

Reviewof20patients withglucocorticoid deficiency (three casesalsowithsaltloss) associated withabsent tearsecretion (19 cases) andachalasia ofthecardia (15cases) revealed neurological abnormalities in17 including hyper-reflexia, muscleweakness, dysarthria, andataxia together withimpaired intelligence andabnormal autonomic function, particularly postural hypotension. Thesefindings indicate that significant neurological problemsarecommoninthis multisystem disorder. (Arch DisChild 1993; 68:779-782)