Oxidative stress and immunological biomarkers in Ankylosing spondylitis patients

Abstract Ankylosing spondylitis (AS) is an inflammatory condition with unrevealed etiology mostly affecting the peripheral joints, the axial skeleton and extra articular structure. In recent years, oxidative stress and immunological factors have been reported as significant factors in AS pathogenesis. The object of this research was to assess the immunological and the oxidative stress factors in AS patients. In this study, 35 patients diagnosed with AS and 40 healthy controls were subjected for clinical examination. Patients were evaluated for Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The biomarkers of oxidative stress were evaluated by biochemical assays. We evaluated the mRNA level of transcription factors, cytokines, chemokines and related miRNAs. T Helper 17 cells (Th17), regulatory T cells (Treg) proportion and cytokines secretion were also assessed. Higher levels of nitric oxide (NO) (p