Effects of continuous renal replacement therapy on the lever of N-terminal pro-B-type natriuretic peptide and C-reactive protein in patients with severe chronic heart failure

Objective To evaluate the value of continuous renal replacement therapy to severe chronic heart failure.Methods Twenty patients with severe chronic heart failure were included in this study.Plasma concentrations of C-reactive protein and N-terminal pro-B-type natriuretic peptide were measured and compared the changes before and after conventional therapy or continuous renal replacement therapy.Results The plasma concentrations of C-reactive protein and N-terminal pro-B-type natriuretic peptide were higher in patients with severe chronic heart failure than those in control group(P0.01).And after treatment,the concentrations decreased more significantly in continuous renal replacement therapy group than those in conventional therapy group(P0.01).Conclusion Continuous renal replacement therapy can decrease the lever of C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with severe chronic heart failure,and may interfere the progression of severe chronic heart failure and improve the cardiac function and prognosis.