Порівняння вмісту біомаркерів запалення у пацієнтів при стенозі сонних артерій та вивчення його змін залежно від прогресування атеросклерозу та виникнення атеросклеротичних ускладнень

Objective. To study the level of homocystein and lipoprotein-associated phospholipase А2 (Lp-PLA2) in patients, suffering atherosclerotic affection of carotid arteries, to estimate its connection with morphological changes of atherosclerotic plaque, the stenosis degree and severity of the disease symptoms. Маterials and methods. Changes of biomarkers in 130 patients, having symptomatic or asymptomatic course of the carotid arteries stenosis course, depending on its degree and structure of atherosclerotic plaque, were analyzed. Results. Trustworthy increase of the Lp-PLА2 level was noted in the patients, suffering symptomatic stenosis of internal carotid artery (ICA) and its asymptomatic course in presence of soft atherosclerotic plaque. Concentration of homocystein did not depend upon the atherosclerotic plaque structure. Conclusion. While comparing of the homocystein and the Lp-PLA2 content in patients, suffering atherosclerotic affection of carotid arteries, there was proved, that the Lp-PLA2 content constitutes a more informative diagnostic criteria for revealing of patients with probable occurrence of an acute disorder of cerebral blood circulation. The Lp-PLA2 level rising in patients with symptomatic ICA stenosis constitutes evidence for the atherosclerotic plaque instability presence.