Supramolecular attack particle: the way cytotoxic T lymphocytes kill target cells.

Balint, S. et al. Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells. Science 368, 897–901 (2020). Article Google Scholar Jerome, T. & Lieberman, J. Perforin: a key pore-forming protein for immune control of viruses and cancer. Sub-Cell. Biochem. 80, 197–220 (2014). Article Google Scholar Halle, S., Halle, O. & Forster, R. Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo. Trends Immunol. 38, 432–443 (2017). CAS Article Google Scholar Jamie, A. et al. Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood 121, 2659–2668 (2013). Article Google Scholar Fella, T. et al. Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells. Sci. Immunol. 4, eaav5445 (2019). Article Google Scholar Download references Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China Jiaqi Liu & Lulu Cai Zenomics Inc., California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA Yanqi Ye You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Lulu Cai. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Liu, J., Ye, Y. & Cai, L. Supramolecular attack particle: the way cytotoxic T lymphocytes kill target cells. Sig Transduct Target Ther 5, 210 (2020). https://doi.org/10.1038/s41392-020-00319-z Download citation Received: 30 June 2020 Revised: 18 August 2020 Accepted: 20 August 2020 Published: 21 September 2020 DOI: https://doi.org/10.1038/s41392-020-00319-z