Acute painful autoimmune neuropathy: A variant of Guillain‐Barré syndrome

2018 
Introduction We present a painful small fibre neuropathy variant of Guillain-Barre syndrome. Methods characterized by antecedent infectious symptoms, hyporeflexia and albuminocytologic dissociation. Results Two patients received intravenous immunoglobulin, and subsequently improved. IgG antibodies in their acute phase sera strongly bound to murine small nerve fibres, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion Our case series suggest that an acute transient immune response can be directed against small nerve fibres, and that patients so affected can exhibit features of Guillain-Barre syndrome. This article is protected by copyright. All rights reserved.
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