Anionic Schiff Base Amphiphiles: Synthesis, Surface, Biocidal and Antitumor Activities

A series of anionic surfactants containing schiff base group was synthesized and their chemical structures were confirmed using elemental analyses, FTIR, 1 H-NMR, and mass spectroscopy. The surface activities of these amphiphiles were determined based on the data of surface tension. Thermodynamics of adsorption and micellization processes of these surfactants in their solutions were also calculated. It was found that these compounds have tendency towards adsorption at the interface and also micelle formation at lower concentrations.Also, these schiff bases amphiphiles have been evaluated for their biocidal activity against bacterial and fungi species and their antitumor activity against three human tumor cells such as HEPG2 (liver), HCF7 (breast) and HCT116 (colon). (Nihal O. Shaker; Fatma H. Abd El-Salam; Bahyia M.El-Sadek; Eman M. Kandeel and Sharbat A. Baker Anionic Schiff Base Amphiphiles: Synthesis, Surface, Biocidal and Antitumor Activities. Journal of American Science 2011;7(5):427-436). (ISSN: 1545-1003). http://www.americanscience.org.