Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling
2017
Background
Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes.
Keywords:
- Folliculogenesis
- Internal medicine
- Endocrinology
- Cancer research
- Growth differentiation factor-9
- SUPERFAMILY
- Ovarian tumor
- Gonadal tumors
- Biology
- Cre recombinase
- Transforming growth factor beta
- Ovary
- Terminal deoxynucleotidyl transferase
- Forkhead box L2
- Molecular biology
- Granulosa cell proliferation
- Cell biology
- Ovarian Granulosa Cell
- Granulosa cell
- Correction
- Source
- Cite
- Save
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