Indoles et quinoléines dérivés de la thiochromannone-3

Abstract The synthesis from 3-thiochromanone of indole and quinoline derivatives is reported. The structures of the compounds obtained, which are analogs of carcinogenic nitrogen polycycles, were determined by means of mass spectrometry and high resolution NMR spectrometry. In the latter case, Nuclear Overhauser Enhancements (NOE) allow the unequivocal determination of structures. Furthermore, direct (or“through space”) 1 H- 1 H couplings are reported and related to the NOE.