Synthesis and biological evaluation of sodium 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate-1,1-dioxide
1994
Abstract The synthesis and β-lactamase inhibitory activity of sodium 2α-(1,2,3-triazol-l-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate-1,1-dioxide 2 (R = Na) is described. Its activity was compared with tazobactam 1 (R = Na). Compound 2 showed excellent synergism in combination with piperacillin (PIPC) and the results were either comparable or superior to tazobactam.
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