Contrastive and Selective Hidden Embeddings for Medical Image Segmentation

Medical image segmentation is fundamental and essential for the analysis of medical images. Although prevalent success has been achieved by convolutional neural networks (CNN), challenges are encountered in the domain of medical image analysis by two aspects: 1) lack of discriminative features to handle similar textures of distinct structures and 2) lack of selective features for potential blurred boundaries in medical images. In this paper, we extend the concept of contrastive learning (CL) to the segmentation task to learn more discriminative representation. Specifically, we propose a novel patch-dragsaw contrastive regularization (PDCR) to perform patch-level tugging and repulsing. In addition, a new structure, namely uncertainty-aware feature re- weighting block (UAFR), is designed to address the potential high uncertainty regions in the feature maps and serves as a better feature re- weighting. Our proposed method achieves state-of-the-art results across 8 public datasets from 6 domains. Besides, the method also demonstrates robustness in the limited-data scenario. The code is publicly available at https://github.com/lzh19961031/PDCR_UAFR-MIShttps://github.com/lzh19961031/PDCR_UAFR-MIS .