Antitumor effective 2-substituted D-Homoestra-1,3,5 (10) -trien-3-yl sulfamate

The present invention relates to 2-substituted D-homo-estra-1,3,5 (10) -trien-3-yl sulfamates of general formula I wherein R and their use for the manufacture of a medicament for the treatment of tumor diseases can be influenced positively by the inhibition of tubulin polymerization. The compounds of the invention are characterized by a D-Homosubstition. can be used for example for the treatment of prostate cancer they have special effect in Tubulinpolymerisationshemmung and.