CLINICAL, HISTOCHEMICAL, AND IMMUNOHISTOCHEMICAL ANALYSIS OF ORAL INTRAVASCULAR PAPILLARY ENDOTHELIAL HYPERPLASIA

The intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion with a vascular origin characterized by the proliferation of endothelial cells that rarely occurs in the oral cavity. The present study aims to describe the clinical, histopathologic, and immunohistochemical characteristics of this lesion. A white, female 43-year-old patient attended the stomatology service complaining of a swelling in lower lip of 2 months’ duration. Physical examination revealed a nodular lesion in the lower lip approximately 0.6 cm in size, sessile, with a bluish coloration, floating, soft to palpation, well delimited, and asymptomatic. An excisional biopsy was performed and after the histopathologic and immunohistochemical analysis (CD34, SMA, HHF35, Ki-67), the diagnosis of IPEH was obtained. No other treatment was given. The patient is under quarterly observation at the service, presenting no clinical evidence of recurrence.