Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats

Jai Shankar K. Yadlapalli,Navdeep Dogra,Anqi W. Walbaum,William D. Wessinger,Paul L. Prather,Peter A. Crooks,Maxim Dobretsov

Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats

2017

Jai Shankar K. Yadlapalli
Navdeep Dogra
Anqi W. Walbaum
William D. Wessinger
Paul L. Prather
Peter A. Crooks
Maxim Dobretsov

Background Morphine-6-O-sulfate (M6S) is a mixed μ-/δ-opioid receptor (OR) agonist and potential alternative to morphine for treatment of chronic multimodal pain.

Keywords:

Modalities
Surgery
Anesthesia
Morphine-6-O-sulfate
Mechanism of action
Medicine
Nociception
Antagonist
ED50
Morphine
Agonist
Naltrindole
Analgesic

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