Metabolic syndrome in adult patients with Prader-Willi syndrome

Background and aims: PradereWilli syndrome (PWS), the most common genetic cause of obesity, is characterized by elevated morbility and mortality in all ages. In this context, non-obese PWS children showed low frequency of metabolic syndrome (MetS), while a comparable prevalence was observed in obese PWS and obese controls. Aim of this study was to estimate the occurrence of MetS and its components in a large group of PWS adults, accord- ing to obesity status. Methods and results: A cross-sectional study was performed in 108 PWS aged 18.0e43.2 years (87 obese and 21 non-obese) and in 85 controls with nonsyndromic obesity matched for age, gender, and BMI with obese PWS.