Synthesis of the Trans-Syn-Trans Perhydrobenzo[f]chromene Ring System
2021
A stereoselective synthesis of the trans-syn-trans
perhydrobenzo[f]chromene skeleton is presented. The target compound 3
was achieved in six steps starting from the (S)-(+)-Wieland-Miescher
ketone. Key steps include the sp2 alkylation at the a-carbon of an unsaturated ketone, Birch-type reductive alkylation, and an acid-catalyzed
cyclization.
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