Periodontal Hastalıklı ve Hiperlipidemili Bireylerde Salya Malondialdehit, Süperokist Dismutaz, Glutatyon, ve Glutatyon Peroksidaz Seviyelerinin Değerlendirilmesi

Ozet Amac: Bu calismada amac periodontal hastalikli ve hiperlipidemili bireylerde salya malondialdehit (MDA), superoksit dismutaz (SOD), glutatyon (GSH) ve glutatyon peroksidaz (GP-x) seviyelerinin degerlendirilmesidir. Yontem: Calisma populasyonunu yaslari 30 ila 57 arasinda degisen 123 hiperlipidemili ve yaslari 31 ila 54 arasinda degisen 68 sistemik olarak saglikli (K) birey olmak uzere toplam 191 birey olusturdu. Hiperlipidemik gruplar diyet onerilen (HD) ve statin onerilen (HS) gruplar olmak uzere iki gruba ayrildi. Butun calisma gruplari periodontal saglikli (s), gingivitisli (g) ve periodontitili (p) olmak uzere uc gruba ayrildi. Tum bireylerin plak indeksi (PI), gingival indeks (GI), cep derinligi (CD), klinik atacman seviyesi (KAS) ve sondlamada kanama varligi yuzdesi (SK-%)' ni iceren olcumlerden olusan klinik periodontal parametreleri kaydedildi. Serum lipidleri ve salya MDA, SOD, GSH ve GP-x seviyeleri degerlendirildi. Sonuclar: Salya MDA ile GI, SK-% ve total kolesterol/yuksek densiteli lipoprotein orani arasindaki pozitif korelasyonlar hiperlipidemili gruplarda anlamli idi. HSs grubunda salya SOD seviyesi, HSp grubuna gore istatistiksel olarak anlamli artis gosterdi. Tartisma: Salya MDA ve SOD seviyeleri, oksidatif stres ile iliskili olarak periodontal hastalik ve hiperlipidemi iliskisinde rol oynayabilen parametreler olabilir. Bu konuda, periodontitis ve hiperlipideminin farkli safhalarina sahip daha genis populasyonlarda, uzun donem ileri calismalara ihtiyac vardir. Anahtar kelimeler: Gingivitis; periodontitis; hiperlipidemi; malondialdehit; superoksit dismutaz; glutatyon; glutatyon peroksidaz. Abstract Objective: The purpose of this study was to evaluate the levels of salivary malondyaldehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GP-x) levels in patients with periodontal disease and hyperlipidemia. Method: One hundred and twenty three subjects with hyperlipidemia aged 30 to 57 and 68 systemically healthy controls (C) aged 31 to 54 were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). All of the groups were divided into three subgroups as healthy (h), gingivitis (g) and periodontitis (p). The clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket (PPD) depth, percentage of bleeding on probing (BOP-%), and clinical attachment level (CAL) were recorded. Serum lipids and salivary MDA, SOD, GSH and GP-x levels were evaluated. Results: MDA is significantly and positively correlated with GI, BOP-% and the ratio of total cholesterol/high density lipoprotein in both hyperlipidemic groups. In the HSh group, salivary SOD level was higher than in the HSp group. Discussion: The salivary MDA and SOD levels are parameters which may play role in the association between periodontal disease and hyperlipidemia. Further longitudinal studies in larger populations with different periodontitis and hyperlipidemia phases are needed to clarify this association. Key words: Gingivitis; periodontitis; hyperlipidemia; malondyaldehyde; superoxide dismutase; glutathione; glutathione peroxidase.