745 The clinical impact of MSI and dMMR in advanced endometrial cancer: the effect of online education on clinician knowledge, competence and confidence

Introduction/Background* This study determined whether online continuing medical education (CME) could improve the knowledge of obstetricians/gynaecologists (obs/gyns) and oncologists (oncs) regarding the relevance of Microsatellite Instability (MSI) and deficient Mismatch Repair (dMMR) for immunotherapy paradigms in advanced endometrial cancer, and increase competence in terms of the application of appropriate diagnostic testing. Methodology A 15-minute online video discussion between two expert faculty was launched for physicians outside the USA October 2020 with data collected to March 2021. Educational effect assessed with repeated-pairs pre-/post-activity- individual participants serving as their own control. 3 multiple-choice, knowledge questions and 1 self-efficacy, 5-point Likert scale confidence question were analysed. McNemar’s test assessed pre- to post-activity change (5% significance level, P .80=Large. Result(s)* 393 obs/gyns and 73 oncs completed pre- and post-activity questions. Positive educational effect was observed for obs/gyns (moderate effect, Cohen’s d=.78, P Conclusion* This on-demand, online video discussion resulted in a positive educational impact. However, education gaps remain evident. Online medical education is valuable in supporting the implementation of new diagnostic strategies into clinical practice as well as identifying areas of continued educational need.