Synthesis of three series of diastereoisomeric bicyclic crown ethers and their stability constants with Group 1A cations

The syntheses of a series of bridged crown ethers are described. Their binding strength to group 1A metals has been compared by determination of the stability constants. An explanation for the wide variation of the measured stability constants is given in terms of the influence of steric interactions on the conformation of the isomers and electrostatic effects occurring within the cavity.