Optimization of a novel two-phase potentiometric titration method of barbiturates with mercury (II)

A two-phase potentiometric titration procedure for barbiturates with mercury(II) was developed. In the new titration procedure the barbituric acid derivative is dissolved in an aqueous borate buffer. An organic phase consisting of chloroform and benzyl alcohol is added, and the vigourously stirred contents of the titration vessel are titrated by a mercury(II) nitrate solution.