Prognostic effects of pulmonary hypertension in patients undergoing cardiac resynchronization therapy

Background: Aim of this study is to investigate the impact of elevated pulmonary artery systolic pressure (PASP) on mortality and the clinical outcome after cardiac resynchronization therapy (CRT). Methods: Ninety-three patients with heart failure were enrolled into this study, and all of them have been treated by CRT for more than 6 months. Based on the level of preoperative PASP, they were divided into three groups (Group I: PASP＞50mmHg, n=29; Group II: 30mmHgCRT significantly improved heart function evaluated by NYHA heart function class and 6 minutes walking distance (6-MWT) (P 0.05. At 6 months after CRT, LVEF increased significantly in all three groups (all P<0.05). Conclusion: Elevated PASP has no prognostic effects on heart function improvement in patients undergone CRT. However, it was associated with worse LV remodeling and increased death due to aggravation of heart failure.