Эндогенная интоксикация при воспалительных заболеваниях кишечника у детей: обоснование эфферентной терапии

The aim of the investigation is to study endogenous intoxication (EI) as one of the mechanisms of the pathogenesis of inflammatory bowel diseases (IBD) in children and substantiation of efferent therapy. Materials and methods. There has been performed the clinical observation of 25 children with IBD aged 5-17 years and 40 children with chronic constipation of various intensity. There have been carried out a complete clinic laboratory examination to assess EI intensity and determined the substances of low and medium molecular mass (SLMMM) on erythrocytes, in blood plasma and urine. Results. IBD in children has been stated to be accompanied by EI, the intensity of which is due to the severity of the process and depends on the character of the involvement. The use of enterosorbtion in patients with IBD reduces the toxic load on the systems of natural detoxication and the risk of infectious and autoimmune complications.