Serum levels and urinary excretion of salusin-α in renal insufficiency

Abstract Salusin-α was recently shown to exert anti-atherosclerotic effects and its potential role as a clinical marker for atherosclerosis has been proposed. We determined serum salusin-α concentrations in 99 patients across a diverse range of renal functions and urinary salusin-α excretions in 12 patients with non-dialyzed renal failure using a highly sensitive and specific radioimmunoassay. Serum salusin-α concentrations in patients with moderate to advanced renal insufficiency (eGFR  2 ) were significantly lower than those with preserved renal function (eGFR > 60 ml/min/1.73 m 2 ) (6.1 ± 2.4 pmol/l vs . 11.8 ± 1.1 pmol/l, p n  = 94, p