Management And Outcome Of The Sickle Cell Patients With Febrile Illness: Adherence To The Evidence-Based Guidelines.

Background: Children with sickle cell disease are at increased risk of serious bacterial infection from loss of splenic function, genetic polymorphism, leukocyte adhesion, microvascular occlusion and leaky gut (1, 2) During the last 20 years, the use of penicillin prophylaxis and pneumococcal vaccination has decreased invasive pneumococcal disease. Many citations in the literature show a low incidence of bacteremia ranging from 1.3-16%. (2, 3, 4, 5, 6, 7) There seems to be a variation between clinicians with the NHLBI recommendation. (8,9,10) Recently there is an emphasis on the healthy microbiome and adverse effects of antibiotics …