Changes of NPY Neurons in the Motor Area in Renovascular Hypertensive Rats

Purpose:To research the changes of NPY neurons in the brain motor area in renovascular hypertensive rats. Methods:Sixty male SD rats were divided randomly into operated group and sham control group ( n =30). In operated rats, renal arteries were constricted bilaterally with silver clips(0.3 mm in internal diameter)to induce RHR. 7 d, 30 d, 90 d after operation the rats were killed, their brains were removed and analysed by ABC immunohistochemistry in the motor area. Result: In control sham group,the density of NPY positive neurons in the motor area decrease with the increase of age, whereas those of the operated group the NPY positive neurons decrease first and then increase, then after remain relatively constant. Comparing the density of NPY of operated group with control group, in the early period(7 d after operation), no significant difference has been found in the density of NPY neuron; in the middle period(30 d after operation) the density of NPY neurons in operated group are lesser than that of control group ( P 0.01); in the late period(90 d after operation), the density of NPY neuron in operated group are greater than control group ( P 0.05). Conclusions:NPY neurons system might mediate the development of hypertension.